Publications

2023

• Cecilia C. Douma and Michael T. Bowser. "Assessing Surface Adsorption in Cyclic Olefin Copolymer Microfluidic Devices Using Two-Dimensional Nano Liquid Chromatography-Micro Free Flow Electrophoresis Separations." Analytical Chemistry, 95, 50, 18379-18387, (2023)
• Matthew B. LeMon, Cecilia C. Douma , Gretchen S. Burke and Michael T. Bowser. "Fabrication of μFFE Devices in COC via Hot Embossing with a 3D-Printed Master Mold." Micromachines, 14, 1728, (2023).

2020

• Sarah K. Anciaux and Michael T. Bowser. “Reduced Surface Adsorption in 3D Printed Acrylonitrile Butadiene Styrene Micro Free-Flow Electrophoresis Devices.” Electrophoresis, 41, 225-234, (2020).

2019

• Brian R. Thompson, Kailey J. Soller, Anthony Vetter, Jing Yang, Gianluigi Veglia, Michael T. Bowser, Joseph M. Metzger. “Cytoplasmic Nucleic Acid-Based XNAs Directly Enhance Live Cardiac Cell Function By a Ca2+ Cycling-Independent Mechanism Via the Sarcomere.” J. Mol. Cell. Cardiol., 130, 1-9 (2019). 

2018

• Kylie B. O’Brien, Anjail Z. Sharrief, Eric J. Nordstrom, Anthony J. Travanty, Mailee Huynh, Megan P. Romero, Katie C. Bittner, Michael T. Bowser, Frank H. Burton. “Biochemical Markers of Striatal Desensitization in Cortical-Limbic Hyperglutamatergic TS- & OCD-like Transgenic Mice.” J. Chem. Neuroanat., 89, 11-20 (2018).
• Alex C. Johnson and Michael T. Bowser. “Micro Free Flow Electrophoresis.” Lab on a Chip, 18, 27-40 (2018).
• Sean K. Dembowski and Michael T. Bowser. “Microfluidic Methods for Aptamer Selection and Characterization.” Analyst, 143, 21-32 (2018).

2017

• Alex C. Johnson and Michael T. Bowser. “High-Speed, Comprehensive, Two Dimensional Separations of Peptides and Small Molecule Biological Amines Using Capillary Electrophoresis Coupled with Micro Free Flow Electrophoresis.” Anal. Chem., 89, 1665-1673 (2017).
• Megan M. Weisenberger and Michael T. Bowser. “In Vivo Monitoring of Amino Acid Biomarkers from Inguinal Adipose Tissue Using Online Microdialysis-Capillary Electrophoresis.” Anal. Chem., 89, 1009-1014 (2017).

2016

• Kailey J. Soller, Jing Yang, Gianluigi Veglia, Michael T. Bowser. “Reversal of Phospholamban Inhibition of the Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA) Using Short, Protein-Interacting RNAs and Oligonucleotide Analogs.” J. Biol. Chem., 291, 21510-21518 (2016). 
• Rachel K. Harstad and Michael T. Bowser. “High-Speed Microdialysis-Capillary Electrophoresis Assays for Measuring Branched Chain Amino Acid Uptake in 3T3-L1 Cells.” Anal. Chem., 88, 8115-8122 (2016). 
• Sarah K. Anciaux, Matthew Geiger, and Michael T. Bowser. “3D Printed Micro Free-Flow Electrophoresis Devices.” Anal. Chem., 88, 7675-7682 (2016). 
• Matthew Geiger and Michael T. Bowser. “Effect of Fluorescent Labels on Peptide and Amino Acid Sample Dimensionality in Two Dimensional nLC x uFFE Separations.” Anal. Chem., 88, 2177-2187 (2016). 
• Kailey J. Soller, Caitlin Walker, Sarah Nelson, Michael T. Bowser, and Gianluigi Veglia. “HAX-1 Structural Studies and Interactions with the SERCA/Phospholamban Complex.” Biophys. J., 110, 394A-395A (2016). 
• Rachel K. Harstad, Alex C. Johnson, Megan M. Weisenberger, and Michael T. Bowser. “Capillary Electrophoresis.” Anal. Chem., 88, 299-319 (2016). 

2015

• Matthew Geiger, Rachel K. Harstad, and Michael T. Bowser. “Effect of Surface Adsorption on Temporal and Spatial Broadening in Micro Free Flow Electrophoresis.” Anal. Chem., 87, 11682-11690 (2015). 
• Kailey J. Soller, Raffaello Verardi, Meng Jing, Neha Abrol, Jing Yang, Naomi Walsh, Vitaly V. Vostrikov, Seth L. Robia, Michael T. Bowser, and Gianluigi Veglia. “Rheostatic Regulation of the SERCA/Phospholamban Membrane Protein Complex Using Non-Coding RNA and Single-Stranded DNA oligonucleotides.” Sci. Rep., 5 (2015).
• Kailey J. Soller, Raffaello Verardi, Vitaly V. Vostrikov, Neha Abrol, Seth L. Robia, Michael T. Bowser, and Gianluigi Veglia. “Sequence-Independent ssDNA Relieves Phospholamban Inhibition of SERCA in a Length Dependent Manner.” Biophys. J., 108, 254A-254 (2015). 

 2014

• Matthew Geiger, Nicholas W. Frost, and Michael T. Bowser. “Comprehensive Multidimensional Separations of Peptides Using Nano-Liquid Chromatography Coupled with Micro Free Flow Electrophoresis.” Anal. Chem., 86, 5136-5142 (2014).
• Thane H. Taylor, Nicholas W. Frost, Michael T. Bowser, and Edgar A. Arriaga. “Analysis of Individual Mitochondria via Fluorescent Immunolabeling with Anti-TOM 22 Antibodies.” Anal. Bioanal. Chem., 406, 1683-1691 (2014).
• Meng Jing, Raffaello Verardi, Gianluigi Veglia, and Michael T. Bowser. “Development of a Sensitive Assay for SERCA Activity Using FRET Detection of ADP.” Anal. Methods, 6, 1468-1474 (2014).
• Yixiao Sheng and Michael T. Bowser. “Isolating Single Stranded DNA Using a Microfluidic Dialysis Device.” Analyst, 139, 215-224 (2014).

2013

• Meng Jing and Michael T. Bowser. ”Tracking the Emergence of High Affinity Aptamers for rhVEGF165 During CE-SELEX Using High Throughput Sequencing.” Anal. Chem., 85, 10761-10770 (2013).
• Amy L. Hogerton and Michael T. Bowser. ”Monitoring Neurochemical Release from Astrocytes Using In Vitro-Microdialysis Coupled with High-Speed Capillary Electrophoresis.” Anal. Chem., 85, 9070-9077 (2013).
• Neil J. Graf and Michael T. Bowser. “Effect of Cross Sectional Geometry on PDMS Micro Peristaltic Pump Performance: Comparison of SU-8 Replica Molding vs. Micro Injection Molding.” Analyst, 138, 5791-5800 (2013).
• Michael T. Bowser. “Introduction to New Frontiers in Bioanalytical Chemistry.” Chem. Rev., 113, 2267-2268 (2013). (Guest Editorial)
• Jing Yang and Michael T. Bowser. “Capillary Electrophoresis-SELEX Selection of Catalytic DNA Aptamers for a Small-Molecule Porphyrin Target.” Anal. Chem., 85, 1525-1530 (2013).

2012

• Yixiao Sheng and Michael T. Bowser. “Size Selective DNA Transport Through a Nanoporous Membrane in a PDMS Microfluidic Device.” Analyst, 137, 1144-1151 (2012).
• Matt Geiger, Amy L. Hogerton, and Michael T. Bowser. ”Capillary Electrophoresis” Anal. Chem., 84, 577-596 (2012). (Invited for inclusion in 2012 Fundamental Reviews Issue)

2011

• Meng Jing and Michael T. Bowser. ”Isolation of DNA Aptamers Using Micro-Free Flow Electrophoresis.” Lab on a Chip, 11, 3703-3709 (2011).
• Meng Jing and Michael T. Bowser. ”A Review of Methods for Measuring Aptamer-Protein Equilibria.” Anal. Chim. Acta., 686, 9-18 (2011).

2010

• Nicholas W. Frost, Meng Jing, and Michael T. Bowser. ”Capillary Electrophoresis” Anal. Chem., 82, 4682-4698 (2010). (Invited for inclusion in 2010 Fundamental Reviews Issue)
• Diana Rosenberg, Elena Kartvelishvily, Maria Shleper, Chandra M.C. Klinker, Michael T. Bowser, and Herman Wolosker. “Neuronal Release of D-Serine: A Physiological Pathway Controlling Extracellular D-Serine Concentration” FASEB Journal, 24, 2951-2961 (2010).
• Nicholas W. Frost and Michael T. Bowser. ”Using Buffer Additives to Improve Analyte Stream Stability in Micro-Free Flow Electrophoresis.” Lab on a Chip, 10, 1231-1236 (2010). (Cover Article)
• Ryan T. Turgeon, Bryan R. Fonslow, Meng Jing, and Michael T. Bowser. ”Measuring Aptamer Equilibria Using Gradient Micro Free Flow Electrophoresis.” Anal. Chem., 82, 3636-3641 (2010).

2009

• Vratislav Kostal, Bryan R. Fonslow, Edgar A. Arriaga, and Michael T. Bowser. “Fast Determination of Mitochondria Electrophoretic Mobility Using Micro-Free Flow Electrophoresis.” Anal. Chem., 81, 9267-9273 (2009).
• Ryan T. Turgeon and Michael T. Bowser. “Micro-Free Flow Electrophoresis: Theory and Applications.” Analytical and Bioanalytical Chemistry, 394, 187-198 (2009).
• Ryan T. Turgeon and Michael T. Bowser. “Improving Sensitivity in Micro-Free Flow Electrophoresis Using Signal Averaging.” Electrophoresis, 30, 1342-1348 (2009).
• Renee K. Mosing and Michael T. Bowser. “Isolating Aptamers Using Capillary Electrophoresis-SELEX (CE-SELEX).” in Nucleic Acid and Peptide Aptamers, Gunter Mayer ed., Humana Press, Methods in Molecular Biology Series, 535, pp. 33-44 (2009).

2008

• Neil J. Graf and Michael T. Bowser. “A Soft-Polymer Piezoelectric Bimorph Cantilever-Actuated Peristaltic Micropump.” Lab on a Chip, 8, 1664-1670 (2008).
• Bryan R. Fonslow and Michael T. Bowser. “Fast Electrophoretic Separation Optimization Using Micro-Free Flow Electrophoresis (u-FFE).” Anal. Chem., 80, 3182-3189 (2008).
• Melissa A. Jones, Ashley Kramer, Tyler Vanadurongvan, Jonathan Maurer, Michael T. Bowser, and Anthony J. Borgerding. “Analysis and Monitoring of Volatile Analytes from Aqueous Solutions by Extractions into the Gas Phase Using Microdialysis Membranes and Coupling to Fast GC.” Anal. Chem., 80, 123-128 (2008).

2007

• Chandra M. Ciriacks and Michael T. Bowser. “4-Fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) a a Fluorogenic Labeling Reagent for the In Vivo Analysis of Amino Acid Neurotransmitters Using Online Microdialysis-Capillary Electrophoresis-Capillary Electrophoresis.” Anal. Chem., 79, 8747-8754 (2007).
• Renee K. Mosing and Michael T. Bowser. “CE-SELEX: Isolating Aptamers Using Capillary Electrophoresis” in Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, James Landers ed., CRC Press, 2007.
• Renee K. Mosing and Michael T. Bowser. “Microfluidic Selection and Applications of Aptamers.” J. Sep. Sci., 30, 1420-1426 (2007).

2006

• Bryan R. Fonslow and Michael T. Bowser. “Optimizing Band Width and Resolution in Micro-Free Flow Electrophoresis.” Anal. Chem., 78, 8236-8244 (2006).
• Robert F. Miller, Michael T. Bowser, and Kylie B. O’Brien. “Methods of Detection for Amino Acid Enantiomers in the Vertebrate Retina” in D-Amino Acids: A New Frontier in Amino Acid and Protein Research - Practical Methods and Protocols, Ryuichi Konno, Hans Bruckner, Antimo D’Aniello, George Fisher, Noriko Fujii and Hiroshi Homma, eds., Nova Science Publishers, New York 2006.
• Kylie B. O’Brien and Michael T. Bowser. “Measuring D-Serine Efflux from Mouse Cortical Brain Slices Using Online Microdialysis-Capillary Electrophoresis.” Electrophoresis, 27, 1949-1956 (2006).
• Michael T. Bowser. “CE-SELEX: In Vitro Selection of Aptamers Using Capillary Electrophoresis.” in 2006 Yearbook of Science & Technology, McGraw-Hill, New York, pp. 41-44 (2006).
• Chandra M. Ciriacks and Michael T. Bowser. “Measuring the Effect of Glutamate Receptor Agonists on Extracellular D-Serine Concentrations in the Rat Striatum Using Online Microdialysis-Capillary Electrophoresis.” Neurosci. Lett., 393, 200-205 (2006).

2005

• Renee K. Mosing, Shaun D. Mendonsa, and Michael T. Bowser. “Capillary Electrophoresis-SLEX Selection of Aptamers With Affinity for HIV-1 Reverse Transcriptase.” Anal. Chem., 77, 6107-6112 (2005).
• Bryan R. Fonslow and Michael T. Bowser. “Free-Flow Electrophoresis on an Anodically Bonded Glass Microchip.” Anal. Chem., 77, 5706-5710 (2005).
• Shaun D. Mendonsa and Michael T. Bowser. “In Vitro Selection of Aptamers with Affinity for Neuropeptide Y Using Capillary Electrophoresis.” J. Amer. Chem. Soc., 127, 9382-9383 (2005).
• Kylie B. O’Brien, Robert F. Miller, and Michael T. Bowser. “D-Serine Uptake in Isolated Larval Tiger Salamander Retinas is Consistent with ASCT Mediated Transport.” Neurosci. Lett., 385, 58-63 (2005).
• Jun Dai, Shaun D. Mendonsa, Michael T. Bowser, Charles A. Lucy, and Pete W. Carr. “Effect of Anionic Additive Type on Ion Pair Formation Constants of Basic Pharmaceuticals.” J. Chromatog. A, 1069, 225-234 (2005).
• Michael T. Bowser. “SELEX: Just Another Separation?” Analyst, 130, 128-130 (2005).
• Michael T. Bowser. “Capillary Electrophoresis” in Encyclopedia of Analytical Science, 2nd ed. (Paul J. Worsfold, Alan Townshend and Colin F. Poole, eds.), Elsevier, Oxford, Vol. 1, pp.334-342 (2005).

2004

• Chandra M. Ciriacks and Michael T. Bowser. “Monitoring D-Serine Dynamics in the Rat Brain Using Online Microdialysis-Capillary Electrophoresis.” Anal. Chem., 76, 6582-6587 (2004).
• Shaun D. Mendonsa and Michael T. Bowser. “In Vitro Selection of High Affinity DNA Ligands for Human IgE Using Capillary Electrophoresis.” Anal. Chem., 76, 5387-5392 (2004).
• Kylie B. O’Brien, Manuel Esguerra, Robert F. Miller, and Michael T. Bowser. “Monitoring Neurotransmitter Release From Isolated Retinas Using Online Microdialysis-Capillary Electrophoresis.” Anal. Chem., 76, 5069-5074 (2004).
• Shaun D. Mendonsa and Michael T. Bowser. “In Vitro Evolution of Functional DNA Using Capillary Electrophoresis.” J. Amer. Chem. Soc., 126, 20-21 (2004).

2003

• Kylie B. O’Brien, Manuel Esguerra, Christina T. Klug, Robert F. Miller, and Michael T. Bowser. “A High-Throughput Online Microdialysis-Capillary Electrophoresis Assay for D-Serine.” Electrophoresis, 24, 1227-1235 (2003).

2001

• Michael T. Bowser and Robert T. Kennedy. “In Vivo Monitoring of Amine Neurotransmitters Using Microdialysis with On-Line Capillary Electrophoresis.” Electrophoresis, 22, 3668-3676 (2001).

2000

• Sulay D. Jhaveri, Romy Kirby, Rick Conrad, Emily J. Maglott, Michael T. Bowser, Robert T. Kennedy, Gary Glick, and Andrew D. Ellington. “Designed Signaling Aptamers that Transduce Molecular Recognition to Changes in Fluorescence Intensity.” J. Amer. Chem. Soc., 122, 2469-2473 (2000). 

1999

• Thomas R. Battersby, Darwin N. Ang, Petra Burgstaller, Simona Jurczyk, Michael T. Bowser, Danielle D. Buchanan, Robert T. Kennedy, and Steven A. Benner. “In Vitro Selection of a Receptor for Adenosine Nucleotides from a Library Incorporating a Cationic Nucleotide Analog.” J. Amer. Chem. Soc., 121, 9781-9789 (1999).
• Michael T. Bowser and David D.Y. Chen. “Monte Carlo Simulation of Error Propagation in the Determination of Binding Constants from Rectangular Hyperbolae. II. Effect of the Maximum Response Range.” J. Phys. Chem. A, 103, 197-202 (1999).

1998

• Michael T. Bowser and David D.Y. Chen. “Monte Carlo Simulation of Error Propagation in the Determination of Binding Constants from Rectangular Hyperbolae. I. Ligand Concentration Range and Binding Constant.” J. Phys. Chem. A, 102, 8063-8071 (1998).
• Michael T. Bowser and David D.Y. Chen. “Higher Order Equilibria and Their Effect on Analyte Migration Behavior in Capillary Electrophoresis.” Anal. Chem., 70 3261-3270 (1998).
• Michael T. Bowser and David D.Y. Chen. “The Effect of Complexation Additives on Analyte Migration Behavior in Capillary Electrochromatography.” Electrophoresis, 19, 1452-1460 (1998). 
• Michael T. Bowser, Andrea R. Kranack, and David D.Y. Chen. “The Properties of Multivariate Binding Isotherms in Capillary Electrophoresis.” Anal. Chem., 70 1076-1084 (1998).
• Michael T. Bowser and David D.Y. Chen. “Recent Developments Towards a Unified Theory for Separation Science.” Electrophoresis, 19, 1586-1589 (1998). 
• Andrea R. Kranack, Michael T. Bowser, Philip Britz-McKibbin, and David D.Y. Chen. “The Effects of a Mixture of Charged and Neutral Additives on Analyte Migration Behavior in Capillary Electrophoresis.” Electrophoresis, 19, 388-396 (1998). 
• Michael T. Bowser and David D.Y. Chen. “Dynamic Complexation in Capillary Electrophoresis.” Electrophoresis, 19, 383-387 (1998). 
• Michael T. Bowser, Andrea R. Kranack, and David D.Y. Chen. “Analyte-Additive Interactions in Nonaqueous Capillary Electrophoresis: A Critical Review.” TrAC-Trends Anal. Chem., 17, 424-434 (1998).

1997

• Michael T. Bowser, Gwendolyn M. Bebault, Xuejun Peng, and David D.Y. Chen. “Redefining the Separation Factor: A Potential Pathway to a Unified Separation Science.” Electrophoresis, 18, 2928-2934 (1997). 
• Xuejun Peng, Michael T. Bowser, Philip Britz-McKibbin, Gwendolyn M. Bebault, Jamie Morris, and David D.Y. Chen. “Quantitative Description of Analyte Migration Behavior Based on Dynamic Complexation in Capillary Electrophoresis with One or More Additives.” Electrophoresis, 18, 706-716 (1997). 
• Michael T. Bowser, Ethan D. Sternberg, and David D.Y. Chen. “Quantitative Description of Migration Behavior of Porphyrins based on the Dynamic Complexation Model in a Nonaqueous Capillary Electrophoresis System.” Electrophoresis, 18, 82-91 (1997). 

1996

• Michael T. Bowser, Ethan D. Sternberg, and David D.Y. Chen. “Development and Application of a Nonaqueous Capillary Electrophoresis System for the Analysis of Porphyrins and Their Oligomers (PHOTOFRIN).” Anal. Biochem., 241, 143-150 (1996). 

1994

• Michael A. Quilliam, William R. Hardstaff, Joseph F. Anacleto, M. Denise LeBlanc, Victoria Stergiopoulos, Karla L. Dick, Michael T. Bowser, Jonathan M. Curtis, Donald J. Embree, P. Greg Sim, and Robert K. Boyd. “Preparation and Certification of Solutions of Perdeuterated Polycyclic Aromatic Compounds Intended For Use as Surrogate Internal Standards.” Fresenius J. Anal. Chem., 350, 109-118 (1994).